Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MRI signal loss due to microcirculation: phantom studies.

S Duewell1, R Wüthrich, A Buck

  • 1Department of Medical Radiology, University Hospital, Zurich, Switzerland.

Magnetic Resonance in Medicine
|May 1, 1990
PubMed
Summary

Researchers developed two novel phantoms to study magnetic resonance imaging (MRI) perfusion effects. These phantoms accurately model capillary flow and spin dynamics, validating MRI techniques for studying blood flow in tissues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Workforce perspective on racial and ethnic equity in early childhood autism evaluation and treatment: "The cornerstone of everything we do".

Autism : the international journal of research and practice·2024
Same author

Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease.

Journal of Crohn's & colitis·2020
Same author

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults.

NeuroImage. Clinical·2019
Same author

Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age.

NeuroImage·2018
Same author

Position statement on radiopharmaceutical production for clinical trials.

EJNMMI radiopharmacy and chemistry·2018
Same author

Benefit of <sup>18</sup>F-fluorocholine PET imaging in parathyroid surgery.

European radiology·2018

Area of Science:

  • Medical Imaging
  • Biophysics

Background:

  • Understanding perfusion effects in MRI is crucial for accurate diagnosis.
  • Existing models may not fully capture complex spin dynamics in capillary networks.

Purpose of the Study:

  • To develop and validate novel phantoms for studying MRI perfusion effects.
  • To investigate signal loss phenomena related to spin dynamics in phantoms simulating capillary flow.

Main Methods:

  • Development of two distinct phantoms: one with linear capillary flow, another with anion exchange resin beads.
  • Imaging of phantoms using standard spin-echo sequences.
  • Quantification of signal intensities at various echo times and comparison with computational models.

Main Results:

Related Experiment Videos

  • Excellent qualitative and quantitative agreement between experimental data and computational predictions of signal loss.
  • Demonstrated that spin-phase phenomena accurately explain perfusion effects.
  • Validation of the developed phantoms as realistic models for capillary networks.

    • Conclusions:

    • The developed phantoms serve as effective tools for studying MRI perfusion effects.
    • Spin-phase phenomena are fundamental to understanding perfusion in MRI.
    • These phantoms can aid in the development and validation of specialized perfusion sequences for clinical applications.