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Related Experiment Videos

Sensory stimulation by time-varying magnetic fields.

M S Cohen1, R M Weisskoff, R R Rzedzian

  • 1Advanced NMR Systems, Inc., Woburn, Massachusetts 01801.

Magnetic Resonance in Medicine
|May 1, 1990
PubMed
Summary

Human volunteers experienced muscular twitches during magnetic resonance imaging (MRI) at high magnetic field gradient slew rates (dB/dt). This suggests a potential stimulation threshold for MRI systems, impacting operational safety.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Imaging

Background:

  • Magnetic Resonance Imaging (MRI) utilizes rapidly changing magnetic field gradients.
  • High gradient slew rates (dB/dt) are crucial for fast imaging but raise safety concerns.
  • Previous research has not extensively documented direct human physiological responses to gradient pulsing.

Purpose of the Study:

  • To investigate human physiological responses to high magnetic field gradient slew rates (dB/dt) during MRI.
  • To assess the safety and potential stimulation effects of rapid gradient pulsing in humans and canines.
  • To identify a potential threshold for peripheral nerve stimulation in MRI.

Main Methods:

  • Two human volunteers underwent MRI scans with a magnetic field gradient dB/dt of 61 T/s RMS.

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  • A canine was subjected to MRI with dB/dt up to 66 T/s RMS.
  • Subjects reported sensory perceptions; canine physiological parameters (ECG) and gross responses were monitored.

    • Main Results:

    • Human volunteers reported experiencing muscular twitches synchronous with gradient pulses.
    • No adverse or sustained effects were observed in human subjects.
    • The canine subject showed no detectable electrocardiogram changes or gross response to gradient pulsing.

    Conclusions:

    • Preliminary findings suggest that peripheral nerve stimulation can occur in humans at dB/dt levels around 61 T/s RMS.
    • These results indicate a potential stimulation threshold that may influence the design and operation of MRI systems.
    • Further research is needed to confirm these anecdotal observations and establish definitive safety guidelines.