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Related Experiment Video

Updated: May 13, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Quantitative transverse flow measurement using optical coherence tomography speckle decorrelation analysis.

Xuan Liu1, Yong Huang, Jessica C Ramella-Roman

  • 1Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA. xliu35@jhu.edu

Optics Letters
|March 5, 2013
PubMed
Summary

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We developed a new method using speckle decorrelation to measure blood flow perpendicular to optical coherence tomography (OCT) imaging. This technique accurately quanties transverse flow speed in phantoms and animal models with high resolution.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Fluid Dynamics

Background:

  • Optical coherence tomography (OCT) is a powerful imaging modality.
  • Quantifying blood flow, especially perpendicular to the imaging beam, remains challenging.
  • Speckle decorrelation analysis offers potential for flow measurement.

Purpose of the Study:

  • To develop and validate an inter-Ascan speckle decorrelation method for quantitative blood flow assessment.
  • To measure blood flow normal to the OCT imaging beam.
  • To evaluate the method's accuracy and resolution.

Main Methods:

  • Inter-Ascan speckle decorrelation analysis was applied to OCT data.
  • Phantom models were used to simulate blood flow.
  • In vivo animal models were utilized for validation.

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  • Transverse flow speed was extracted and analyzed.

    • Main Results:

    • The proposed method accurately quantifies transverse blood flow speed.
    • High spatial and temporal resolution was achieved.
    • Validation in both phantom and animal models confirmed method's efficacy.

    Conclusions:

    • Inter-Ascan speckle decorrelation is a viable method for quantitative blood flow assessment.
    • The technique provides high-resolution measurement of flow normal to the OCT beam.
    • This advancement has implications for various biomedical imaging applications.