Testing the usefulness of twin formation theory: the tocopherols and vitamin D

The theoretical and empirical search for biologically and pharmacologically active molecules has long been of interest. In 1965 Revici proposed a class of biologically and pharmacologically active molecules which he described as having twin formations. Twin formations are defined as molecules containing two or more adjacent carbon atoms having the same induced electrical charge. An examination of recently discovered facts about the biological activity of the tocopherol family and of vitamin D lends support to this concept, which if true, could greatly facilitate selection of promising pharmacological substances for testing.