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Updated: May 13, 2026

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Advances in targeting signal transduction pathways

James A McCubrey1, Linda S Steelman, William H Chappell

  • 1Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, USA. mccubreyj@ecu.edu

Oncotarget
|March 5, 2013
PubMed

Insights

Recent advances enhance understanding of signal transduction pathways, targeted therapies, and genetic mechanisms of drug sensitivity and resistance. This knowledge aids in developing novel treatments for various diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Signal transduction pathways are complex and crucial in disease pathogenesis.
  • Targeted therapies offer promising treatment strategies for various diseases.
  • Genetic factors significantly influence patient response to targeted therapies.

Purpose of the Study:

  • To review recent advances in understanding signal transduction pathways in disease.
  • To discuss the development and application of targeted therapies.
  • To explore genetic mechanisms of sensitivity and resistance to targeted therapies.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies on signal transduction pathways and targeted therapies.
  • Synthesis of information on genetic mutations and drug resistance.

Main Results:

  • Significant progress in elucidating complex signaling pathways.
  • Identification of specific inhibitors targeting key pathway components.
  • Discovery of genetic mutations affecting patient sensitivity to targeted therapies.
  • Uncovering of genetic mechanisms driving resistance to targeted therapies.

Conclusions:

  • Advances in understanding signal transduction pathways and targeted therapies are rapidly evolving.
  • Genetic insights are crucial for personalized medicine and overcoming therapeutic resistance.
  • This knowledge facilitates the development of more effective and tailored treatment strategies.

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