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Updated: May 13, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
[Hypereosinophilic syndrome]
F Moosig1, G Richardt, C Merten
1Klinikum Bad Bramstedt und Universitätsklinikum Schleswig-Holstein, Oskar-Alexander-Str. 26, 24576 Bad Bramstedt. f.moosig@klinikumbb.de
Der Internist
|March 5, 2013
Summary
Hypereosinophilic syndrome involves high eosinophil counts and organ damage. Diagnosis and identifying the cause are key for treatment and prognosis, especially when the heart is involved.
Area of Science:
- Hematology
- Immunology
- Pathology
Context:
- Hypereosinophilic syndrome (HES) is a complex group of disorders.
- Characterized by elevated blood eosinophils and resultant organ damage.
- Requires thorough investigation to determine underlying causes and affected organs.
Purpose:
- To outline the diagnostic approach for HES.
- To highlight the prognostic significance of organ involvement, particularly cardiac.
- To review current and emerging therapeutic strategies.
Summary:
- HES diagnosis necessitates identifying the specific cause and extent of organ damage.
- Cardiac involvement significantly worsens patient outcomes.
- Current treatments include glucocorticoids and steroid-sparing agents, with targeted therapies like tyrosine kinase inhibitors for specific causes.
Impact:
- Improved diagnostic work-up aids in tailored treatment selection.
- Understanding prognostic factors like cardiac involvement guides clinical management.
- Advances in molecular pathogenesis pave the way for novel therapies, including antibody treatments.
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