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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: May 13, 2026

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
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Published on: September 17, 2021

Oxidative stress in Mexicans with diffuse cutaneous systemic sclerosis.

M P Cruz-Domínguez1, D H Montes-Cortes, I M Olivares-Corichi

  • 1Research Division, Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional "La Raza", IMSS, Seris y Zaachila S/N, Col. La Raza, CP 02990 Mexico City, Mexico. drapilarcd@prodigy.net.mx

Rheumatology International
|March 5, 2013
PubMed
Summary

Diffuse cutaneous systemic sclerosis (dcSSc) patients exhibit increased oxidative stress and reduced antioxidant capacity compared to healthy individuals. Oxidative stress markers correlate with uric acid levels, suggesting a link to endothelial dysfunction and atherosclerosis.

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Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Diffuse cutaneous systemic sclerosis (dcSSc) is an autoimmune disease characterized by fibrosis and vascular complications.
  • Oxidative stress (OS) and reduced antioxidant capacity are implicated in systemic sclerosis pathogenesis.
  • Investigating OS biomarkers and their relationship with clinical markers is crucial for understanding disease progression.

Purpose of the Study:

  • To compare OS biomarkers and plasma antioxidant capacity (ACP) between Mexican dcSSc patients and healthy controls.
  • To explore the association of OS and ACP with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA).
  • To evaluate differences in OS between early and late dcSSc stages.

Main Methods:

  • Cross-sectional study including 28 dcSSc patients and 28 healthy controls.
  • Measurement of lipoperoxidation products (malondialdehyde) and protein oxidation products (carbonyls, dityrosines).
  • Assessment of plasma antioxidant capacity (ACP), CRP, ESR, and UA levels.

Main Results:

  • dcSSc patients showed significantly higher OS and decreased ACP compared to controls (p < 0.001).
  • OS levels were similar in early and late dcSSc stages.
  • Anti-Scl-70 autoantibody positivity was associated with higher OS (p < 0.05).
  • Significant correlations were found between UA and OS biomarkers (malondialdehyde, dityrosines, carbonyls).
  • Elevated ESR (71%) and CRP (40%) were observed in a substantial proportion of dcSSc patients.

Conclusions:

  • Mexican dcSSc patients exhibit elevated lipid and protein OS with reduced ACP.
  • UA levels are directly correlated with OS biomarkers in dcSSc.
  • Elevated ESR and CRP suggest a pro-inflammatory state and potential for endothelial dysfunction and accelerated atherogenesis in dcSSc.