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GSL-enriched membrane microdomains in innate immune responses

Hitoshi Nakayama1, Hideoki Ogawa, Kenji Takamori

  • 1Juntendo University Laboratory for Biochemistry, Faculty of Health Care and Nursing, Chiba, Japan.

Archivum Immunologiae Et Therapiae Experimentalis
|March 5, 2013
PubMed
Summary

Lactosylceramide (LacCer)-enriched membrane microdomains in neutrophils act as pattern-recognition receptors (PRRs). These microdomains, interacting with CD11b/CD18, are crucial for innate immunity and phagocytosis of microbes.

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