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IgG4-related inflammatory pseudotumors mimicking multiple meningiomas
Takayoshi Nishino1, Joe Toda, Tomoya Nakatsuka
1Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
Japanese Journal of Radiology
|March 5, 2013
Summary
IgG4-related disease can affect the brain, presenting as unusual lesions that mimic tumors. Early recognition of these IgG4-related pseudotumors is crucial to avoid unnecessary surgery.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibroinflammatory condition.
- Intracranial manifestations of IgG4-RD typically include hypophysitis, dural thickening, and trigeminal nerve enlargement.
Observation:
- This case report details a patient with systemic IgG4-RD.
- Neuroimaging revealed supratentorial lesions resembling meningiomas.
- Intracranial internal carotid artery walls showed thickening and contrast enhancement.
Findings:
- The observed IgG4-RD lesions mimicked meningiomas on neuroimaging.
- Thickening and enhancement of intracranial arteries were noted.
- This represents the first reported case of these specific intracranial findings in IgG4-RD.
Implications:
- Accurate diagnosis of IgG4-related intracranial pseudotumors is essential.
- Avoidance of unnecessary surgical interventions for misdiagnosed lesions.
- Highlights the diverse and potentially misleading intracranial presentations of IgG4-RD.
