The mechanism of tissue-restricted antigen gene expression by AIRE
Kristina Zumer1, Kalle Saksela, B Matija Peterlin
1Department of Virology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.
Journal of Immunology (Baltimore, Md. : 1950)
|March 5, 2013
Abstract:
The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.
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