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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
The CD28/B7 pathway: a novel regulator of plasma cell function
1Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA. mnjau@emory.edu
Advances in Experimental Medicine and Biology
|March 5, 2013
Summary
The CD28/B7 pathway regulates plasma cell function. This pathway can inhibit or stimulate plasma cells, impacting antibody production during inflammation.
Area of Science:
- Immunology
- Cell Biology
Background:
- The CD28/B7 pathway is crucial for T cell activation and function.
- CD28 and its ligands B7.1/B7.2 are expressed on plasma cells, but their role is largely unknown.
Purpose of the Study:
- To investigate the role of CD28 expression in plasma cell function.
- To understand how the CD28/B7 pathway influences antibody production.
Main Methods:
- Review of recent studies examining CD28 expression on plasma cells.
- Analysis of reported stimulatory and inhibitory effects of CD28.
Main Results:
- CD28 exhibits both stimulatory and inhibitory effects on plasma cells.
- The CD28/B7 interaction regulates plasma cell function under homeostatic conditions.
Conclusions:
- The CD28/B7 pathway plays a regulatory role in plasma cell function.
- Perturbation of this pathway during inflammation can increase antibody production from plasma cells.
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