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Updated: May 13, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
Cerebral malaria: protection by erythropoietin
Anne-Lise Bienvenu1, Stephane Picot
1Malaria Research Unit, SMITH ICBMS UMR CNRS, UCBL, INSA Lyon, Lyon, France.
Abstract:
Cerebral malaria (CM) is still responsible for unacceptable death rate, while new antimalarial drugs were recently developed. CM pathophysiology shares essential biological features with cerebral ischemia. Because erythropoietin (Epo) was demonstrated to reduce mortality rate during experimental cerebral ischemia, in the early 2000, we wondered whether Epo could help to reduce the burden of CM. There is now evidence that Epo high doses could prevent early mortality during cerebral malaria. This evidence was obtained first using mice model of cerebral malaria, and later confirmed by prospective clinical trial in endemic area. High doses of Epo are needed to cross the blood-brain barrier and to favor the cytoprotective versus hematopoietic effect of this pleiotropic cytokine.
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