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Updated: May 13, 2026

Optogenetic Activation of Intrinsic Cardiac Autonomic Neurons in Excised Perfused Mouse Hearts
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Optogenetic Activation of Intrinsic Cardiac Autonomic Neurons in Excised Perfused Mouse Hearts

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Cardiac optogenetics.

Emilia Entcheva1

  • 1Department of Biomedical Engineering, Department of Physiology and Biophysics, and Institute for Molecular Cardiology, Stony Brook University, Stony Brook, New York, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|March 5, 2013
PubMed
Summary
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Optogenetics uses light-sensitive microbial opsins for precise control of cellular activity. This review explores its emerging potential for cardiac applications, building on neuroscience successes.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Cardiology

Background:

  • Optogenetics enables precise optical control of biological functions using microbial opsins.
  • This technique offers high specificity and spatiotemporal resolution, surpassing traditional methods.
  • Initially applied to neuroscience, optogenetics has shown significant impact in understanding brain function.

Purpose of the Study:

  • To review the principles and applications of optogenetics in cardiac tissue.
  • To discuss the potential of optogenetics for cardiac research and therapeutic strategies.
  • To highlight the early stage and future possibilities of cardiac optogenetics.

Main Methods:

  • Review of optogenetic tools, including light-gated ion channels and pumps.
Keywords:
channelrhodopsinlight-sensitive ion channelsoptical mapping

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Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
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Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity

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Last Updated: May 13, 2026

Optogenetic Activation of Intrinsic Cardiac Autonomic Neurons in Excised Perfused Mouse Hearts
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Optogenetic Activation of Intrinsic Cardiac Autonomic Neurons in Excised Perfused Mouse Hearts

Published on: March 28, 2025

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
12:52

Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity

Published on: March 5, 2020

  • Analysis of existing optogenetic applications in neuroscience.
  • Exploration of implementation strategies for cardiac applications.

    • Main Results:

    • Optogenetics provides fast, specific excitatory or inhibitory control in excitable cells.
    • The field has rapidly advanced in neuroscience since 2005.
    • Cardiac optogenetics, emerging since 2010, has fewer than a dozen publications.

    Conclusions:

    • Optogenetics presents a promising frontier for cardiac research and potential interventions.
    • Further development and research are needed to fully realize its potential in the heart.
    • This review provides a perspective on the future possibilities of optogenetics in cardiology.