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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: May 13, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

[Childhood brain tumors].

Kristiina Nordfors1, Olli Lohi, Hannu Haapasalo

  • 1TAYS, lastentautien vastuualue.

Duodecim; Laaketieteellinen Aikakauskirja
|March 6, 2013
PubMed
Summary
This summary is machine-generated.

Pediatric brain tumors are a major cause of childhood illness and death. While treatments like surgery and radiation offer a high cure rate, long-term quality of life issues persist for survivors.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Related Experiment Videos

Last Updated: May 13, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Area of Science:

  • Pediatric oncology
  • Neuro-oncology
  • Childhood cancer research

Context:

  • Brain tumors represent the second most frequent neoplastic disease in children, following leukemias.
  • They constitute a major cause of mortality and morbidity in pediatric populations.
  • Significant advancements have improved survival rates, with approximately 75% of children achieving complete recovery.

Purpose:

  • To outline the current landscape of pediatric brain tumor treatment and outcomes.
  • To highlight the challenges associated with long-term survivorship.
  • To underscore the importance of addressing both oncological and quality-of-life aspects in pediatric neuro-oncology.

Summary:

  • Treatment for pediatric brain tumors primarily involves surgical excision.
  • Malignant tumors often require additional cytotoxic agents and radiotherapy.
  • Despite improved recovery rates, long-term complications frequently impact survivors' quality of life.

Impact:

  • Improved understanding of pediatric brain tumor treatment efficacy and challenges.
  • Highlights the need for comprehensive, long-term follow-up care for childhood cancer survivors.
  • Informs future research directions focusing on mitigating long-term sequelae and enhancing quality of life for pediatric brain tumor patients.