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Assessment of left ventricular dyssynchrony in dipper and non-dipper hypertension

Mehmet Fatih Karakas1, Eyup Buyukkaya, Mustafa Kurt

  • 1Department of Cardiology, Mustafa Kemal University, Tayfur Ata Sokmen Medical School, Hatay, Turkey. mfkarakas@hotmail.com

Blood Pressure
|March 6, 2013
PubMed

Insights

Non-dipping blood pressure patterns are linked to impaired left ventricular synchrony in both normal and hypertensive individuals. This finding suggests a connection between blood pressure circadian rhythms and heart function.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiac Electrophysiology

Background:

  • Ventricular dyssynchrony is a key factor in heart failure progression.
  • While ventricular dyssynchrony is known to coexist with hypertension and heart failure, its relationship with blood pressure circadian rhythms remains unexplored.
  • This study investigates the impact of blood pressure dipping patterns on left ventricular synchrony.

Purpose of the Study:

  • To examine left ventricular synchrony in normotensive and hypertensive individuals with different blood pressure circadian rhythms (dipper vs. non-dipper).
  • To determine if non-dipping blood pressure is associated with increased ventricular dyssynchrony.

Main Methods:

  • 142 participants were classified into four groups: Normotensive-Dipper (NT-D), Normotensive-Non-dipper (NT-ND), Hypertensive-Dipper (HT-D), and Hypertensive-Non-dipper (HT-ND).
  • Left ventricular dyssynchrony was assessed using color-coded tissue Doppler imaging.

Main Results:

  • Non-dippers exhibited higher 24-hour and nighttime blood pressure compared to dippers in both normotensive and hypertensive groups.
  • The incidence of ventricular dyssynchrony was significantly higher in the hypertensive group (47.2%) than the normotensive group (24.3%).
  • Ventricular dyssynchrony was more frequent in Hypertensive-Non-dippers (58.8%) compared to Hypertensive-Dippers (36.8%), and elevated in Normotensive-Non-dippers compared to Normotensive-Dippers.

Conclusions:

  • A non-dipping blood pressure pattern is associated with impaired left ventricular contraction synchrony.
  • This impairment was observed in both normotensive and hypertensive participants.
  • The findings suggest that hypertension's short- and long-term effects on the myocardium may contribute to these synchrony issues.
Abstract

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