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The effect of acetaminophen ingestion on cortico-spinal excitability
Alexis R Mauger1, James G Hopker
1Endurance Research Group, School of Sport and Exercise Sciences, Faculty of Science, University of Kent, Kent, England.
Abstract:
Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.
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