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Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

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Published on: December 31, 2015

Newborn transepidermal water loss values: a reference dataset.

Maeve M Kelleher1, Michelle O'Carroll, Aine Gallagher

  • 1Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.

Pediatric Dermatology
|March 6, 2013
PubMed
Summary

This study establishes normal values for transepidermal water loss (TEWL), a key indicator of infant skin barrier function. Findings provide a reference dataset for healthy term and preterm neonates using a standardized measurement method.

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Area of Science:

  • Neonatal dermatology
  • Pediatric skin physiology
  • Barrier function research

Background:

  • Transepidermal water loss (TEWL) is a critical, non-invasive measure of the skin's barrier function.
  • Establishing normative data for TEWL in neonates is essential for identifying potential skin health issues early in life.

Purpose of the Study:

  • To determine and establish reference values for transepidermal water loss (TEWL) in a large cohort of neonates.
  • To provide a benchmark dataset for neonatal skin barrier function using an open-chamber system.

Main Methods:

  • Utilized data from the Cork BASELINE Birth Cohort Study.
  • Measured TEWL in 1,036 full-term and 18 late preterm neonates within 96 hours of birth.
  • Employed a standardized, validated open-chamber system in an environmentally controlled setting.

Main Results:

  • Full-term neonatal TEWL measurements showed a normal distribution with a mean of 7.06 ± 3.41 g/m²/hr.
  • Preterm neonatal TEWL measurements averaged 7.76 ± 2.85 g/m²/hr.
  • This represents the largest evaluation of TEWL in a normal-term neonatal population to date.

Conclusions:

  • The study successfully established a reference dataset for neonatal TEWL.
  • These findings are crucial for assessing skin barrier function in newborns.
  • The data supports the use of open-chamber systems for standardized neonatal TEWL assessment.