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Related Concept Videos

Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...

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Related Experiment Video

Updated: May 13, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Cortical ependymoma with unusual histologic features.

Annie Hiniker1, Han S Lee, Susan Chang

  • 1Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA. Anne.Hiniker@ucsfmedctr.org

Clinical Neuropathology
|March 6, 2013
PubMed
Summary

This study details a rare cortical ependymoma in a young woman, highlighting its unique features and potential relationship with other gliomas. The patient recovered well after surgery, showing no signs of recurrence.

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Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain
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Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain

Published on: June 1, 2015

Related Experiment Videos

Last Updated: May 13, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain
06:58

Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain

Published on: June 1, 2015

Area of Science:

  • Neuro-oncology
  • Neuropathology

Background:

  • Cortical ependymomas are rare gliomas primarily involving the cerebral cortex.
  • This case presents a unique presentation of a cortically based non-enhancing lesion.

Observation:

  • A 19-year-old woman with new-onset seizures had a large, cortically based lesion.
  • The lesion exhibited classic ependymal cytology, GFAP/EMA positivity, and ultrastructural features like cilia.
  • Tumor displayed infiltrative growth and mucin-filled microcystic spaces.

Findings:

  • Morphologic, immunohistochemical, and ultrastructural analyses confirmed ependymal features.
  • The tumor showed characteristics overlapping with angiocentric glioma and myxopapillary ependymoma.
  • Gross total resection resulted in no evidence of recurrence.

Implications:

  • This case supports a relationship between cortical ependymoma and angiocentric glioma.
  • Cortical ependymomas may exhibit both classic and myxopapillary features.
  • Understanding these variations aids in diagnosis and treatment of rare brain tumors.