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Related Experiment Video

Updated: May 13, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

SEEKING and depression in stroke patients: an exploratory study.

Marina Farinelli1, Jaak Panksepp, Laura Gestieri

  • 1Clinical Psychology Service, Villa Bellombra, Rehabilitation Hospital, Bologna, Italy. marina.farinelli@unibo.it

Journal of Clinical and Experimental Neuropsychology
|March 6, 2013
PubMed
Summary

Brain lesions impacting the SEEKING system in stroke patients are linked to reduced reward-seeking behavior and increased depression. This suggests the anterior subcortical-cortical midline system is crucial for human SEEKING.

Related Experiment Videos

Last Updated: May 13, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • The SEEKING concept, a drive to pursue environmental rewards, is well-studied in animals but less understood in humans, particularly those with brain damage.
  • Previous research has primarily focused on animal models, leaving a gap in understanding SEEKING mechanisms in the human brain, especially following neurological injury.

Purpose of the Study:

  • To explore the effects of brain lesions on the SEEKING system in stroke patients.
  • To investigate the relationship between lesions in specific brain regions and SEEKING behaviors.
  • To examine the correlation between SEEKING system dysfunction and depression symptoms in stroke survivors.

Main Methods:

  • An exploratory behavioral study was conducted with stroke patients.
  • Lesion locations in the brain were analyzed for potential impact on the SEEKING system.
  • SEEKING scores and depression scores were compared between patients with and without specific brain lesions.

Main Results:

  • Stroke patients with lesions in anterior, medial, and/or subcortical regions exhibited significantly lower SEEKING scores.
  • These patients also demonstrated higher depression scores compared to control subjects without such lesions.
  • The findings indicate a correlation between specific brain lesion locations and diminished reward-seeking tendencies and increased depressive symptoms.

Conclusions:

  • The anterior subcortical-cortical midline system appears to be centrally involved in mediating SEEKING behaviors in humans.
  • Damage to this system, as seen in stroke patients with specific lesions, can impair reward-driven motivation and increase vulnerability to depression.
  • These findings extend previous animal research and highlight the limbic system's core role in human SEEKING and emotional regulation.