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Published on: June 20, 2018
Expression of p53 protein after nonablative rejuvenation: the other side of the coin
Moetaz El-Domyati1, Tarek S El-Ammawi, Walid Medhat
1Department of Dermatology, Al-Minya University, Al-Minya, Egypt. moetazeldomyati@yahoo.com
Background:
Disturbance of p53 expression may play an important role in the pathogenesis of ultraviolet (UV) light-induced skin cancer as well as photoaging.
Objectives:
To objectively evaluate the potential effect of nonablative facial rejuvenation on p53 expression.
Participants And Methods:
Thirty patients with Fitzpatrick skin type III to IV were divided into five groups. Each group underwent a different nonablative modality: radiofrequency (RF), intense pulsed light (IPL), electro-optical synergy (ELOS) (combined RF and IPL), 1,320-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, and 2,940-nm erbium-doped (Er):YAG laser minipeel. Skin biopsies were obtained before treatment, by the end of treatment, and 3 months after treatment. Biopsies were also taken from 30 controls. Quantitative evaluation of p53 was performed using computer image analysis for immunostained tissues.
Results:
P53 expression was statistically significantly greater at the end of IPL (p = .02) and ELOS (p = .02) treatments than before treatment but was statistically insignificantly lower (p > .05) 3 months after treatment than at the end of treatment. No significant differences (p > .05) were observed in p53 level after RF, 1,320-nm Nd:YAG, and 2,940-nm Er:YAG mini-peel treatments from baseline.
Conclusions:
The increase in epidermal p53 expression after IPL treatment could increase the risk of skin neoplasia by intense pulsed light-induced DNA damage which may lead to dysregulation of apoptosis and initiation of skin cancer.
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