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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

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Structural brain plasticity in adult learning and development.

Martin Lövdén¹, Elisabeth Wenger, Johan Mårtensson

¹Aging Research Center, Karolinska Institutet & Stockholm University, Gävlegatan 16, 113 30 Stockholm, Sweden; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany.

Neuroscience and Biobehavioral Reviews

|March 6, 2013

Summary

New research shows that the adult brain

Keywords:

Aging Brain volume Experience-dependent plasticity Learning Neuroplasticity Structural brain changes Structural brain plasticity

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Area of Science:

Neuroscience
Neuroimaging
Developmental Psychology

Background:

Adult human brain grey matter structure is sensitive to changes in experiential demands.
Brain plasticity models, including animal studies, offer insights into experience-dependent brain changes.
Age differences in structural brain plasticity are increasingly recognized.

Purpose of the Study:

To review magnetic resonance imaging (MRI) research on experience-dependent structural brain changes in adults.
To integrate findings with existing brain plasticity models.
To propose future research directions for understanding these changes and their implications for adult development and aging.

Main Methods:

Review of recent magnetic resonance imaging (MRI) studies.
Synthesis of research on brain plasticity, including animal models.
Analysis of age-related differences in structural plasticity.

Main Results:

Documented structural changes in adult grey matter due to altered experiences.
Established a link between experiential demands and brain structure modifications.
Highlighted the role of experience-dependent plasticity in adult development and aging.

Conclusions:

Experience significantly shapes the adult human brain's structure.
Further research is needed to elucidate the mechanisms of experience-dependent structural plasticity.
Understanding these changes can enhance knowledge of adult development and aging processes.