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Should the STAIR criteria be modified for preconditioning studies?
Michael M Wang1, Guohua Xi, Richard F Keep
1Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA ; Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan USA.
Preconditioning (PC) shows promise for brain protection in animal models, but clinical translation requires caution. Guidelines are needed to ensure safety, relevant models, and optimal timing for PC therapies.
Area of Science:
- Neuroscience
- Translational Medicine
- Clinical Neurology
Background:
- Preconditioning (PC) stimuli demonstrate neuroprotective effects in animal models against various neuronal insults.
- Potential clinical applications include surgery and acute neuronal injury scenarios, but translation faces challenges.
Purpose of the Study:
- To review the applicability of consensus criteria for preclinical studies to preconditioning research.
- To discuss additional considerations for improving the translation of preconditioning findings into clinical practice.
Main Methods:
- Review of existing consensus criteria from STAIR and NINDS for preclinical studies.
- Discussion of specific considerations for preconditioning studies, including safety, dosage, model relevance, and timing.
Main Results:
- Preclinical studies show promise for preconditioning, but clinical validation has been disappointing.
- Existing guidelines need adaptation for preconditioning research to enhance translational utility.
Conclusions:
- Caution is advised when translating preclinical preconditioning findings to clinical applications.
- Key areas for attention include safety, dosage, matching preclinical models to human conditions, and optimizing stimulus timing relative to injury.
