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Prevailing genotypes of hepatitis C virus in Saudi Arabia: a systematic analysis of evidence

Suhair M Abozaid1, Mohamed Shoukri, Ahmad Al-Qahtani

  • 1Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Annals of Saudi Medicine
|March 6, 2013
PubMed

Insights

Hepatitis C virus (HCV) genotype 4 is the most common in Saudi Arabia, followed by genotype 1. This meta-analysis confirms the prevalence of these HCV genotypes in the region.

Area of Science:

  • Hepatology
  • Virology
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) genotype 4 is prevalent in the Middle East, but its distribution requires further clarification in certain regions.
  • Genotype distribution of HCV in Saudi Arabia has not been conclusively determined.

Purpose of the Study:

  • To conduct a meta-analysis of existing literature to identify and confirm the predominant HCV genotypes in Saudi Arabia.

Main Methods:

  • A systematic search for studies reporting HCV genotypes in Saudi Arabia was performed.
  • Meta-analysis was conducted on data from 18 studies published between 1995 and 2011, encompassing 2277 specimens.

Main Results:

  • HCV genotype 4 was the most prevalent (1198 cases), followed by genotype 1 (617 cases), genotype 3 (119 cases), and genotype 2 (82 cases).
  • Significant heterogeneity in prevalence estimates was observed across the included studies.

Conclusions:

  • HCV genotype 4 is the most prevalent in Saudi Arabia, succeeded by genotype 1.
  • Further research into HCV genotype and subtype distribution is recommended.
Abstract

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