Related Experiment Videos
Celiac disease presenting as rickets in Saudi children
Asaad Assiri1, Anjum Saeed, Ahmed AlSarkhy
1Department of Pediatric, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Annals of Saudi Medicine
|March 6, 2013
Summary
Rickets can be an early sign of celiac disease in Saudi children. Pediatricians should screen for this malabsorption disorder in children with unexplained rickets.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Malabsorption Syndromes
Background:
- Rickets, often linked to vitamin D and calcium deficiencies, can also indicate underlying malabsorption issues like celiac disease.
- Unexplained rickets in children necessitates a thorough investigation into potential gastrointestinal causes.
Purpose of the Study:
- To determine the frequency of celiac disease diagnosis in Saudi children presenting with unexplained rickets.
- To evaluate the diagnostic yield of celiac disease screening in this pediatric population.
Main Methods:
- A retrospective review of patient records over a 10-year period at a tertiary pediatric gastroenterology unit.
- Inclusion criteria: children referred for unexplained rickets or osteomalacia, screened for celiac disease.
- Celiac disease diagnosis followed European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria, including serology and small bowel biopsy.
Main Results:
- Twenty-six children (mean age 9.5 years) with unexplained rickets were evaluated.
- Celiac disease was confirmed in 10 out of 26 patients (38.4%) via small bowel biopsy.
- All confirmed cases showed positive serological markers: antiendomyseal and antitissue transglutaminase antibodies.
Conclusions:
- Rickets is a notable, not uncommon, presenting symptom of celiac disease in Saudi children.
- Pediatricians should maintain a high index of suspicion for celiac disease in children with unexplained rickets.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:21Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
01:20Inborn Errors of Metabolism
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life