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Template-based correction of high-order aberration in keratoconus
Jason D Marsack1, Jos J Rozema, Carina Koppen
1University of Houston College of Optometry, Visual Optics Institute, Houston, TX 77204, USA. jmarsack@optometry.uh.edu
Summary
This study on keratoconus (KC) eyes found that template-based high-order aberration (HOA) corrections significantly reduce optical errors. These common HOA corrections show potential for improving vision in multiple KC patients.
Area of Science:
- Ophthalmology
- Optometry
- Corneal Science
Background:
- Keratoconus (KC) is characterized by corneal morphological changes.
- These changes are associated with common high-order aberration (HOA) structures.
- HOA corrections may offer cross-patient applicability in KC.
Purpose of the Study:
- To classify KC eyes into subgroups based on HOA characteristics.
- To simulate the optical performance of common HOA corrections within these subgroups.
- To assess the efficacy of template-based HOA corrections for KC.
Main Methods:
- Recorded HOAs in 111 KC eyes over a 5-mm pupil.
- Subgrouped eyes based on HOA structure similarity.
- Applied principal components analysis to derive template corrections.
- Simulated correction and measured residual higher order root mean square wavefront error (HORMS).
Main Results:
- 81% of KC eyes were successfully subgrouped.
- Template corrections reduced median HORMS from 2.14 to 0.97 μm.
- An average 51% reduction in HORMS was observed across test eyes.
- Some eyes achieved HORMS within gas-permeable lens wear limits.
Conclusions:
- Common HOA structures, particularly vertical coma, allow for template-based corrections.
- All evaluated KC eyes showed reduced HORMS with template corrections.
- HOA correction templates demonstrate potential for improving visual quality in KC.
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