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Related Experiment Video

Updated: May 13, 2026

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses
08:10

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Published on: January 15, 2020

H5N1 pathogenesis studies in mammalian models.

Jessica A Belser1, Terrence M Tumpey

  • 1Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States.

Virus Research
|March 6, 2013
PubMed
Summary

Highly pathogenic avian influenza (H5N1) poses a pandemic threat. Understanding H5N1 virus and host responses in mammalian models is crucial for developing effective countermeasures against this severe influenza subtype.

Keywords:
Avian influenzaFerretH5N1InfluenzaMammalianMicePathogenesis

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Influenza A Virus Studies in a Mouse Model of Infection
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Influenza A Virus Studies in a Mouse Model of Infection

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Influenza A Virus Studies in a Mouse Model of Infection
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Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Area of Science:

  • Virology
  • Immunology
  • Pathogenesis

Background:

  • Avian influenza H5N1 viruses cause severe human disease and potential pandemics.
  • Expanding host and geographic ranges necessitate understanding virus-host interactions.
  • Mammalian models are vital for studying H5N1 pathogenesis and virulence.

Purpose of the Study:

  • To review H5N1 virus behavior and host responses in mammals.
  • To identify viral and host factors influencing H5N1 pathogenicity.
  • To highlight potential targets for H5N1 prevention and therapy.

Main Methods:

  • Analysis of H5N1 virus virulence in various mammalian species.
  • Evaluation of host responses in inbred and outbred mammalian models.
  • Examination of viral gene products and molecular determinants of H5N1 disease.

Main Results:

  • H5N1 virus exhibits variable virulence depending on host species and inoculation route.
  • Host responses significantly modulate H5N1 disease severity.
  • Specific viral factors contribute to H5N1 pathogenicity in vivo.

Conclusions:

  • Mammalian models provide critical insights into H5N1 influenza pathogenesis.
  • Understanding virus-host dynamics reveals targets for therapeutic and preventative strategies.
  • This review aids in mitigating the global health threat posed by avian influenza viruses.