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Echovirus 30 outbreak associated with a high meningitis attack rate in Thrace, Greece

Elpis Mantadakis1, Vasiliki Pogka, Androniki Voulgari-Kokota

  • 1Department of Pediatrics, Democritus University of Thrace Faculty of Medicine, Thrace, Greece. emantada@med.duth.gr

The Pediatric Infectious Disease Journal
|March 6, 2013
PubMed

Insights

A 2012 outbreak in Thrace affected 105 children with fever, headache, and abdominal pain. Echovirus 30 was identified as the cause of meningitis in over half of the confirmed cases.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • An increase in pediatric cases presenting with fever, headache, and abdominal pain was observed in Thrace during summer 2012.
  • Initial clinical presentations suggested a possible infectious etiology requiring further investigation.

Purpose of the Study:

  • To identify the causative agent of the observed illness in children in Thrace.
  • To determine the clinical characteristics and attack rate of the identified viral infection, specifically meningitis.

Main Methods:

  • Clinical examination of 105 children presenting with specific symptoms.
  • Laboratory analysis including hemograms and cerebrospinal fluid analysis.
  • Isolation and identification of Echovirus 30 from fecal and cerebrospinal fluid samples.

Main Results:

  • Echovirus 30 was isolated from 105 children, with 33 hospitalized.
  • Cerebrospinal fluid analysis revealed mild to moderate pleocytosis.
  • The meningitis attack rate among confirmed echoviral illness cases was 51.9%.

Conclusions:

  • Echovirus 30 was the primary cause of the pediatric meningitis outbreak in Thrace in 2012.
  • Echovirus 30 infections can lead to significant rates of meningitis in children.

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