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Related Experiment Video

Updated: May 13, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Electrospinning covalently cross-linking biocompatible hydrogelators.

Kelly M Schultz1, Laura Campo-Deaño, Aaron D Baldwin

  • 1Department of Chemical and Biomolecular Engineering and Center for Molecular and Engineering Thermodynamics, University of Delaware, 150 Academy St., Newark, DE 19716, USA.

Polymer
|March 6, 2013
PubMed
Summary

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Electrospinning hydrogels during reaction requires understanding gelation. This study correlates hydrogel rheology with fiber formation, enabling engineered microstructures for biological applications.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Materials Engineering

Background:

  • Hydrogel materials are often homogeneous at the micrometer scale.
  • Electrospinning creates sub-micrometer to micrometer fibers, offering a route to microstructured materials.
  • Processing reactive hydrogels via electrospinning necessitates understanding their gelation kinetics and rheology near the liquid-solid transition.

Purpose of the Study:

  • To correlate the structure of electrospun fibers from a covalently cross-linking hydrogelator with its gelation transition and kinetics.
  • To investigate the influence of gelation rheology on the formation of stable electrospun fibers.
  • To demonstrate the retention of microstructural features in electrospun hydrogel fibers.

Main Methods:

  • Utilizing multiple particle tracking microrheology (MPT) to measure gelation kinetics.
Keywords:
electrospinninghydrogelsmicrorheology

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Last Updated: May 13, 2026

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  • Employing polyethylene oxide (PEO) as a carrier polymer in a poly(ethylene glycol)-high molecular weight heparin (PEG-HMWH) hydrogel system.
  • Electrospinning both reacting and equilibrated hydrogel systems, followed by PEO dissolution.

    • Main Results:

    • Established a correlation between material rheology and the formation of stable electrospun fibers.
    • Confirmed that microstructural features of electrospun fibers are retained, irrespective of whether spinning occurs during reaction or from an equilibrated gel.
    • Validated the covalent nature of the hydrogel network through retained microstructures.

    Conclusions:

    • The study successfully correlated hydrogel rheology with electrospun fiber formation.
    • Electrospinning of covalently cross-linking hydrogels allows for the retention of microstructural features.
    • This technique enables the engineering of materials with specific microstructural length scales for biological applications.