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Updated: May 13, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

PML Surfs into HIPPO Tumor Suppressor Pathway

Sabrina Strano1, Francesca Fausti, Silvia Di Agostino

  • 1Molecular Chemoprevention Group, Molecular Medicine Area, Regina Elena National Cancer Institute Rome, Italy.

Frontiers in Oncology
|March 6, 2013
PubMed

Insights

Promyelocytic leukemia protein (PML) enhances tumor suppression by integrating with HIPPO and p53 pathways. This crosstalk network amplifies the anti-tumor response against various oncogenic insults.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Tumor suppressor responses typically involve growth arrest, proliferation inhibition, apoptosis, senescence, and differentiation.
  • Tumor suppression is increasingly understood as a result of integrated and synergistic pathway activities, including linear and lateral signaling.
  • Lateral crosstalk signaling often involves common nodal proteins.

Purpose of the Study:

  • To discuss the role of Promyelocytic leukemia protein (PML) in functional crosstalk with the HIPPO and p53 tumor suppressor pathways.
  • To highlight PML's contribution to an integrated tumor suppressor network.

Main Methods:

  • Literature review and discussion of existing research on PML, HIPPO, and p53 pathways.
  • Analysis of signaling crosstalk mechanisms.

Main Results:

  • Promyelocytic leukemia protein (PML) participates in functional crosstalk with both the HIPPO and p53 tumor suppressor pathways.
  • PML possesses its own anti-tumor activity.
  • PML contributes to the assembly of a superior, integrated network for tumor suppression.

Conclusions:

  • PML plays a crucial role in coordinating multiple tumor suppressor pathways.
  • The integrated network involving PML, HIPPO, and p53 is vital for maximizing the tumor suppressor response.
  • This coordinated action is essential for combating diverse oncogenic insults.
Keywords:
interactionpathwaysignalingtranscriptiontumor suppression

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