[A myth of Jekyll and Hyde?]
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Updated: May 13, 2026

Split-Ubiquitin Based Membrane Yeast Two-Hybrid (MYTH) System: A Powerful Tool For Identifying Protein-Protein Interactions
Published on: February 1, 2010
Björn Schlier1, Tania M Lincoln
1Fachbereich Psychologie, Universität Hamburg. bjoern.schlier@studium.unihamburg.de
Aim:
People widely believe that schizophrenia goes along with a split personality. Little is known, however, about the consequences of this belief. In this study, we tested whether the split-personality-belief is associated with stigmatization of schizophrenia.
Methods:
A sample of 416 persons was recruited from the general population. In an online-survey, the split-personality-belief, the stereotypes dangerousness and unpredictability/incompetence and individual discrimination (i. e. desired social distance) of persons diagnosed with schizophrenia were assessed by self-report.
Results:
The split-personality-belief was associated with increased perceived dangerousness, unpredictability/incompetence and desired social distance. Both stereotypes mediated the relationship of split-personality-belief and desired social distance.
Conclusion:
The split-personality-belief is associated with and may even contribute to stigmatiziation of persons with schizophrenia. Efforts to reduce stigmatization are likely to benefit from battling this misconception.
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