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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

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Selenium is inversely associated with interleukin-6 in the elderly.

C-K Tseng¹, C-T Ho, H-S Hsu

¹Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.

The Journal of Nutrition, Health & Aging

|March 6, 2013

Summary

Low serum selenium levels are linked to higher inflammation (interleukin-6) in Taiwanese elderly in long-term care. Monitoring selenium status is recommended for this population.

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Published on: May 1, 2017

Area of Science:

Gerontology
Nutritional Science
Immunology

Background:

Selenium is an essential trace element with antioxidant properties.
Aging is associated with decreased serum selenium concentrations.
Inflammation, indicated by interleukin-6 (IL-6), is a concern in the elderly.

Purpose of the Study:

To investigate the association between serum selenium levels and the inflammatory cytokine interleukin-6 (IL-6) in elderly individuals residing in Taiwanese long-term care facilities.

Main Methods:

A cohort of 336 elderly subjects (≥65 years) from Taiwanese long-term care facilities was studied.
Serum selenium concentration < 80 μg/L defined selenium deficiency.
Multiple logistic and linear regression analyses examined the relationship between selenium deficiency, IL-6 quartiles, and serum selenium levels.

Main Results:

The prevalence of selenium deficiency was 35.6% in men and 43.2% in women.
Higher quartiles of IL-6 were significantly associated with an increased odds of selenium deficiency, showing a dose-response effect (p < 0.05).
Serum selenium was inversely associated with IL-6 levels after adjusting for confounders.

Conclusions:

Serum selenium concentration is inversely associated with the inflammatory cytokine IL-6 in institutionalized elderly Taiwanese.
Monitoring serum selenium levels is advisable for elderly individuals in long-term care settings.