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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Imaging cortical damage and dysfunction in multiple sclerosis.

Massimo Filippi1, Maria A Rocca, Mark A Horsfield

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. filippi.massimo@hsr.it

JAMA Neurology
|March 6, 2013
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis causes brain damage in the cerebral cortex, visible with magnetic resonance imaging. This review covers MRI techniques assessing this progressive cortical injury.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple sclerosis (MS) involves both white and gray matter damage.
  • Cerebral cortical damage in MS is increasingly recognized and contributes to disability.
  • Pathological findings correlate with in vivo imaging of cortical injury.

Purpose of the Study:

  • To review magnetic resonance imaging (MRI) techniques for assessing cortical damage in MS.
  • To summarize findings on the progression and characteristics of MS-related cortical injury.
  • To highlight the role of quantitative MRI in evaluating cortical dysfunction.

Main Methods:

  • Review of studies utilizing conventional MRI sequences.
  • Analysis of data from advanced quantitative MRI techniques.
  • Correlation of MRI findings with clinical aspects of multiple sclerosis.

Main Results:

  • In vivo MRI consistently detects focal and diffuse cortical damage in MS patients.
  • Cortical injury in MS progresses over time.
  • The extent of cortical damage is only partially explained by white matter abnormalities.

Conclusions:

  • MRI is crucial for visualizing and quantifying cortical damage in MS.
  • Understanding cortical injury progression is key to managing MS.
  • Quantitative MRI offers valuable insights into MS-related brain pathology.