Vacuolar-type proton pump ATPases: acidification and pathological relationships
1Faculty of Pharmaceutical Sciences, Doshisha Woman's College, Kohdo, Kyotanabe, Kyoto, Japan. kwada@dwc.doshisha.ac.jp
Histology and Histopathology
|March 6, 2013
Summary
The vacuolar H(+)-translocating ATPase (V-ATPase) is crucial for cellular functions and disease. This review highlights V-ATPase targeting mechanisms and its roles in macrophages and cancer cells.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Background:
- Vacuolar H(+)-translocating ATPase (V-ATPase) is a vital proton pump.
- It participates in diverse cellular processes including endocytosis, bone resorption, and acid-base balance.
Purpose of the Study:
- To review recent advancements in V-ATPase targeting mechanisms.
- To discuss the functions of V-ATPase in macrophages and cancer cells.
Main Methods:
- Literature review of recent research on V-ATPase targeting.
- Analysis of V-ATPase functions in specific cell types.
Main Results:
- V-ATPase exhibits varied compositions and targeting depending on cellular location.
- V-ATPase targeting is implicated in a range of diseases.
- The enzyme plays significant roles in macrophages and cancer cells.
Conclusions:
- Understanding V-ATPase targeting is crucial for disease intervention.
- V-ATPase's role in macrophages and cancer cells warrants further investigation for clinical applications.
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