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Related Experiment Video

Updated: May 13, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

[Interleukin-1-mediated diseases].

D Holzinger¹, H Becker, A M Jacobi

¹Institut für Immunologie, Universitätsklinikum Münster, Münster.

|March 6, 2013

Summary

This summary is machine-generated.

Interleukin-1 (IL-1) diseases stem from excessive IL-1 beta. Early diagnosis and treatments like IL-1 inhibitors improve outcomes for rare and common inflammatory conditions.

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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

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Published on: March 1, 2011

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Last Updated: May 13, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Area of Science:

Immunology
Inflammation Biology
Genetics

Context:

Interleukin-1 (IL-1) mediated diseases are characterized by excessive IL-1 beta production.
These conditions encompass a spectrum from rare hereditary autoinflammatory syndromes to common diseases like gout and type 2 diabetes.
Delayed recognition and treatment can lead to severe long-term complications, including amyloidosis.

Purpose:

To review the pathogenic mechanisms, diagnostic approaches, and therapeutic strategies for IL-1 mediated inflammatory diseases.
To highlight recent advancements in the management of these conditions.
To underscore the broad clinical relevance of IL-1 dysregulation.

Summary:

IL-1 mediated diseases result from overproduction of IL-1 beta, causing symptoms such as arthritis, fever, and inflammation.
While some are rare hereditary conditions (e.g., cryopyrin-associated periodic fever syndromes), IL-1 also drives common diseases like gout and type 2 diabetes.
Modern treatments include monoclonal antibodies targeting IL-1 and IL-1 receptor antagonists, significantly improving patient outcomes, especially when initiated early.

Impact:

Improved understanding of IL-1's role in both rare and common inflammatory diseases.
Advances in diagnostics and therapeutics offer new hope for patients with debilitating conditions.
Early intervention strategies can prevent severe long-term complications and enhance quality of life.