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Local toxicity from local anesthetic polymeric microparticles.

J Brian McAlvin1, Gally Reznor, Sahadev A Shankarappa

  • 1Department of Medicine, Medicine Critical Care Program, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Anesthesia and Analgesia
|March 6, 2013
PubMed
Summary

Sustained-release local anesthetics like lidocaine and bupivacaine cause similar tissue injury, regardless of drug type or concentration. Intrinsic myotoxicity does not predict this injury, warranting caution near muscle and nerve.

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