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Published on: December 21, 2019
Novel function of Trim44 promotes an antiviral response by stabilizing VISA
Bo Yang1, Jie Wang, Yanming Wang
1School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
Abstract:
Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.
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