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Updated: May 13, 2026
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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm
Hiroki Tanaka1, Nobuhiro Zaima, Takeshi Sasaki
1Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Plos One
|March 6, 2013
Summary
Abdominal aortic aneurysm (AAA) involves changes in the adventitial vaso vasorum (VV). Smooth muscle cell proliferation narrows VV, reducing oxygen supply to the aortic wall, a new insight into AAA pathology.
Area of Science:
- Vascular Biology
- Pathophysiology
- Atherosclerosis Research
Background:
- Abdominal aortic aneurysm (AAA) is prevalent in older adults, but its exact causes are unclear.
- In AAA, thrombus limits oxygen to the aortic wall, relying on adventitial vaso vasorum (VV) for supply.
- Understanding VV changes is crucial for elucidating AAA pathophysiology.
Purpose of the Study:
- To investigate alterations in the adventitial VV wall within AAA.
- To clarify the histopathological mechanisms contributing to AAA development and progression.
Main Methods:
- Histopathological examination of adventitial VV in AAA tissue.
- Immunohistological analysis to identify cell proliferation.
- Assessment of HemeB signals in the aortic wall.
Main Results:
- Significant intimal hyperplasia observed in adventitial VV within the AAA sac.
- Smooth muscle cell proliferation identified, leading to VV luminal stenosis.
- Reduced HemeB signals detected in the AAA sac wall compared to the neck region.
Conclusions:
- Adventitial VV stenosis and associated aortic wall malperfusion are novel findings in AAA pathology.
- These discoveries offer new perspectives on the mechanisms underlying abdominal aortic aneurysms.
- Further research into VV function may reveal new therapeutic targets for AAA.
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