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Related Experiment Video

Updated: May 13, 2026

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

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Small vessel vasculitis associated with cocaine use.

William Rietkerk¹, Fredrick Pereira, Jennifer Poste

¹New York Medical College, Valhalla, USA. billrietkerk@gmail.com

|March 7, 2013

Summary

Cocaine use can cause small vessel vasculitis, often linked to the adulterant levamisole. This condition can mimic autoimmune vasculitis, especially with nasal lesions.

Area of Science:

Rheumatology
Toxicology
Dermatology

Background:

Small vessel vasculitis is a rare but serious condition.
Cocaine use has been associated with various systemic complications.
Levamisole is a common adulterant found in illicit cocaine.

Observation:

A 51-year-old woman presented with symptoms suggestive of vasculitis.
The patient had a history of cocaine use.
Midline destructive nasal lesions were a prominent clinical feature.

Findings:

The patient was diagnosed with cocaine-induced small vessel vasculitis.
Levamisole, a cocaine adulterant, is strongly implicated in the pathogenesis.
Distinguishing this from autoimmune vasculitis is crucial for appropriate management.

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Implications:

Early identification of cocaine-induced vasculitis is essential to prevent further complications.
Diagnostic criteria and tests are proposed to differentiate from autoimmune vasculitis.
Awareness among clinicians regarding levamisole's role in vasculitis is important.