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Related Experiment Video

Updated: May 13, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

Procalcitonin in pediatrics.

Lucia Pacifico¹, John F Osborn, Fabio Natale

¹Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

Advances in Clinical Chemistry

|March 7, 2013

Summary

This summary is machine-generated.

Procalcitonin (PCT) shows clinical usefulness in adults for severe infections. This review examines PCT

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Area of Science:

Biochemistry
Pediatric Medicine
Clinical Microbiology

Background:

Procalcitonin (PCT) has been extensively studied for clinical utility in adult severe infections over 20 years.
Debate exists regarding PCT's role in diagnosing and managing severe infections in adults.
Clinician familiarity with PCT use in pediatric populations is limited.

Purpose of the Study:

To review the clinical significance of procalcitonin (PCT) in pediatric severe conditions.
To evaluate PCT as a biomarker for systemic inflammation, infection, and sepsis in children.

Main Methods:

Literature review of procalcitonin (PCT) studies.
Analysis of PCT's role in pediatric systemic inflammation, infection, and sepsis.

Main Results:

Growing body of literature on PCT in adults, but less in pediatrics.
PCT is a potential marker for severe pediatric conditions.
PCT's utility in pediatric sepsis and inflammation requires further investigation.

Conclusions:

Procalcitonin (PCT) is a valuable marker for severe pediatric conditions.
Further research is needed to fully establish PCT's role in pediatric infection and sepsis management.