Related Experiment Video
Updated: May 13, 2026
09:14
Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
[Selectins as adhesion molecules and potential therapeutic target].
J Jebali1, C Jeanneau, A Bazaa
1Laboratoire des Venins et Toxines, Institut Pasteur de Tunis 13, Place Pasteur 1002 Tunis Belvédère, Tunisie.
Archives De L'Institut Pasteur De Tunis
|March 7, 2013
Summary
Selectins are adhesion molecules crucial for immune responses, mediating cell interactions via sugar recognition. This review details their structures, functions, and roles in inflammation and cancer.
Area of Science:
- Molecular Biology
- Immunology
- Glycobiology
Context:
- Selectins are key adhesion molecules mediating leukocyte trafficking and immune cell interactions.
- They recognize specific carbohydrate structures (sialyl-Lewis antigens) on their ligands.
- These interactions are vital at the blood-vessel wall interface during inflammation.
Purpose:
- To review the current understanding of selectin and selectin-ligand structures and functions.
- To update knowledge on the involvement of selectins in pathophysiological processes.
- To highlight their roles in inflammation and tumor development.
Summary:
- Selectins (L-, P-, and E-selectin) are structurally homologous adhesion molecules utilizing their Carbohydrate Recognition Domain (CRD) to bind specific glycans.
- Selectin-ligand interactions are fundamental to regulating inflammatory and immunological responses.
- This review consolidates knowledge on selectin biology and their implications in disease.
Impact:
- Provides a comprehensive overview of selectin-mediated cell adhesion.
- Enhances understanding of selectin roles in inflammatory diseases and cancer progression.
- Serves as a resource for researchers in immunology, glycobiology, and molecular medicine.
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Related Concept Videos
01:25Selectins
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
01:15Activation of Integrins
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
01:20Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...
01:20Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...
01:10Integrins
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...