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Related Experiment Video

Updated: May 13, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Pimecrolimus for psoriasis.

Jean Ayer¹, Helen S Young

¹The University of Manchester, Salford Royal Hospital, Dermatology Research Centre, Manchester Academic Health Science Centre, Manchester, UK.

Expert Opinion on Pharmacotherapy

|March 7, 2013

Summary

Pimecrolimus offers an effective, off-license topical treatment for psoriasis, especially on the face and in skin folds. Oral pimecrolimus shows promise but requires further clinical trials for recommendation.

Area of Science:

Dermatology
Pharmacology

Background:

Pimecrolimus, a calcineurin inhibitor, is explored for psoriasis treatment.
It is an off-license therapy, valuable for resistant cases or those with adverse effects to other treatments.

Purpose of the Study:

To review the efficacy and role of topical and oral pimecrolimus in psoriasis management.
To compare pimecrolimus treatments with existing psoriasis therapies.

Main Methods:

Comprehensive literature review of topical and oral pimecrolimus in psoriasis.
Searches conducted via PubMed and Embase databases.

Main Results:

Topical pimecrolimus demonstrates effectiveness, particularly for facial and intertriginous psoriasis.
Oral pimecrolimus presents potential as a systemic alternative.

Related Experiment Videos

Last Updated: May 13, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Conclusions:

Topical pimecrolimus is a viable, albeit off-license, option for specific psoriasis types.
Oral pimecrolimus requires Phase III trials to confirm its therapeutic role and inform recommendations.