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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
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Lyme nephritis.

Meryl P Littman1

  • 1Department of Clinical Studies-Philadelphia, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104-6010, USA. merylitt@vet.upenn.edu

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001)
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

Lyme nephritis (LN) affects dogs, causing kidney damage and protein loss. Early screening for proteinuria in seropositive dogs is crucial due to a lack of predictive tests and effective prevention strategies.

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Area of Science:

  • Veterinary Medicine
  • Nephrology
  • Immunology

Background:

  • Lyme nephritis (LN) is a serious kidney complication of Lyme disease in dogs.
  • It is characterized by protein-losing nephropathy and glomerulonephritis.
  • Certain breeds, like Labrador and Golden Retrievers, are predisposed.

Purpose of the Study:

  • To review current knowledge on Lyme nephritis in dogs.
  • To identify gaps in understanding regarding its pathogenesis, risk factors, and treatment.
  • To emphasize the need for early detection and monitoring.

Main Methods:

  • Literature search of PubMed using keywords related to Lyme disease, nephritis, and retrievers.
  • Review of publications on canine and human cases of immune-mediated glomerulonephritis.
  • Synthesis of findings from veterinary and human data.

Main Results:

  • Lyme nephritis occurs in <1-2% of seropositive dogs, typically at 5-6 years of age.
  • Clinical signs include protein-losing nephropathy, hypertension, and renal failure.
  • Human cases show variable response to antimicrobials and immunosuppressive therapy.

Conclusions:

  • There is no established experimental model for Lyme nephritis.
  • Predictive tests for high-risk dogs are lacking, necessitating universal screening for proteinuria.
  • Further research is needed to understand pathogenesis, risk factors, and optimize treatment protocols.