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Updated: May 13, 2026

Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG

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Fengycin C produced by Bacillus subtilis EA-CB0015.

Valeska Villegas-Escobar¹, Isabel Ceballos, John J Mira

¹Grupo GIPAB, Departamento de Ingeniería de Procesos, Universidad EAFIT, Medellín, Colombia. vvilleg2@eafit.edu.co

Journal of Natural Products

|March 7, 2013

Summary

A novel fengycin C compound was identified from Bacillus subtilis EA-CB0015, demonstrating potent antifungal activity against Mycosphaerella fijiensis. This discovery offers potential for new biocontrol strategies in agriculture.

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Single-cell Analysis of Bacillus subtilis Biofilms Using Fluorescence Microscopy and Flow Cytometry

Single-cell Analysis of Bacillus subtilis Biofilms Using Fluorescence Microscopy and Flow Cytometry

Published on: February 15, 2012

Area of Science:

Microbiology
Plant Pathology
Biochemistry

Background:

Mycosphaerella fijiensis causes Black Sigatoka, a devastating disease in banana plants.
Biological control agents are sought to manage plant pathogens sustainably.

Purpose of the Study:

To isolate and characterize bioactive compounds from Bacillus subtilis EA-CB0015 with antifungal properties.
To evaluate the efficacy of these compounds against Mycosphaerella fijiensis.

Main Methods:

Isolation of Bacillus subtilis from banana phyllosphere.
Dual plate culture technique for antifungal activity assessment.
Purification using solid-phase extraction and HPLC.
Structural elucidation via mass spectrometry and amino acid analysis.

Main Results:

Bacillus subtilis EA-CB0015 supernatant showed 89% inhibition against Mycosphaerella fijiensis.
A new fengycin isoform, fengycin C, was isolated and characterized.
Fengycin C exhibits structural variations from known fengycins A and B.

Conclusions:

Bacillus subtilis EA-CB0015 produces fengycin C, a potent antifungal agent.
Fengycin C represents a promising candidate for biological control of Black Sigatoka disease.