Related Experiment Videos
[Ten years of renal transplantation in children]
J Simón González1, I Zamora Martí, F García Ibarra
1Sección de Nefrología, Hospital Infantil La Fe, Valencia.
Insights
Pediatric kidney transplant outcomes show excellent patient survival, with living related donors (LD) achieving 100% and cadaveric donors (CD) achieving 90% two-year survival. Graft survival rates were also favorable, particularly in younger recipients.
Area of Science:
- Pediatric Nephrology
- Transplantation Surgery
- Immunology
Context:
- Kidney transplantation in children is a critical treatment for end-stage renal disease.
- Understanding long-term graft and patient survival is essential for optimizing pediatric transplant protocols.
- Donor type (living related vs. cadaveric) and recipient age are key factors influencing transplant success.
Purpose:
- To evaluate the outcomes of kidney transplantation in a pediatric population.
- To compare graft and patient survival rates based on donor type and recipient age.
- To assess renal function post-transplant using serum creatinine levels.
Summary:
- A retrospective analysis of 114 kidney transplants in 90 children (ages 1-15) from 1979-1988.
- Living related donor (LD) transplants showed superior patient survival (100% at 2 years) compared to cadaveric donor (CD) transplants (90% at 2 years).
- First graft survival at 2 years was 78% for LD and 68% for CD. Younger recipients (1-5 years) had slightly lower graft survival rates than older children (6-15 years).
Impact:
- Demonstrates the efficacy and long-term viability of kidney transplantation in children.
- Highlights the benefit of utilizing living related donors for improved transplant outcomes.
- Provides valuable data for refining surgical techniques and post-operative care strategies in pediatric transplant recipients.
Abstract:
One hundred and fourteen kidney transplants (87 first and 27 second and thirds) were performed in 90 children aged 1 to 15 years during the period 1979-1988; 44% were under 10 years, 14% under 5 and 8% under 3 years of age. The renal grafts were from living related donor (LD) in 30 cases and from cadaveric donor (CD) in 84; 91 were from adult donors and 23 from pediatric ones. The actuarial survival rate of the patients at one and two years was 100% in the LD and 92 and 90% respectively in the CD group. The actuarial survival rate of the first graft at one two years was 98% and 78% in the LD and 83% and 68% in the CD group. When gathered for the receptor age the actuarial survival rate of the first graft was 78 and 67% in the 1-5 years group (n = 19) and 86 and 71% in the 6-15 years one (n = 68). Serum creatinine level was 0.9 +/- 0.4 mg/dl three months, 1.2 +/- 0.7 mg/dl at one year, an 1.8 +/- 1.2 mg/dl at two years among the 50 transplants with a follow-up over two years.