Related Experiment Video
Updated: May 13, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma
Xia-bing Tang1, Xiao-hui Shen, Lei Li
1Department of Otolaryngology, Head and Neck Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, PR China.
Objective:
The aim of present study was to investigate the expression of SOX2, a key transcription factor, in LSCC and to assess its prognostic significance.
Methods:
SOX2 expression of 161 LSCC tissues was detected by immunohistochemistry using a tissue microarray and statistically analyzed for its correlation with clinicopathological charateristics and patient outcome. In addition, SOX2 expression was also observed in 20 self-paired fresh LSCC tissues by western blot.
Results:
SOX2 was overexpressed in LSCC tissues as compared to the corresponding adjacent normal tissues. SOX2 expression was significantly associated with tumour T classification (p<0.001), clinical stage (p<0.001), lymph node metastasis (p=0.007) and recurrence (p=0.001). Univariate analysis revealed that patients with high SOX2 expression were significantly related to overall survival (p<0.001). Multivariate survival analysis further demonstrated that SOX2 expression was an independent prognostic factor for LSCC patients.
Conclusion:
SOX2 may contribute to the malignant progression of laryngeal squamous cell carcinoma (LSCC), and present as a useful prognostic marker and a potential therapeutic target for LSCC patients.
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