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B Cell Activation and Differentiation

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Related Experiment Video

Updated: May 13, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

[B-cell neoplasms with plasmacellular and plasmablastic differentiation].

F Fend¹, L Quintanilla-Martínez

¹Institut für Pathologie und Neuropathologie, Universitätsklinik und Comprehensive Cancer Center Tübingen, Liebermeisterstr. 8, 72076 Tübingen, Deutschland. falko.fend@med.uni-tuebingen.de

|March 7, 2013

Summary

Diagnosing plasma cell myeloma (PCM) and B-cell lymphomas requires careful integration of clinical, morphological, and immunophenotypic data. This review aids in distinguishing these conditions and related entities for accurate diagnosis.

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Flow Cytometric Characterization of Murine B Cell Development

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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Related Experiment Videos

Last Updated: May 13, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Flow Cytometric Characterization of Murine B Cell Development

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Area of Science:

Hematology
Oncology
Immunology

Context:

Plasma cell malignancies, including plasma cell myeloma (PCM), originate from terminally differentiated B-cells.
Distinguishing PCM from mature B-cell lymphomas with plasmablastic differentiation presents diagnostic challenges.
Accurate diagnosis relies on integrating clinical, morphological, and immunophenotypic analyses.

Purpose:

To review common diagnostic challenges in differentiating plasma cell myeloma from B-cell lymphomas.
To provide criteria for distinguishing small B-cell lymphomas, PCM, and high-grade B-cell lymphomas with plasmablastic differentiation.
To highlight the role of molecular markers and viral detection in diagnosing these hematological neoplasms.

Summary:

Plasma cell malignancies are neoplastic proliferations of plasma cells, with PCM being a common hematological neoplasm.
Morphological and immunophenotypic plasmablastic differentiation is observed in various mature B-cell lymphomas, complicating diagnosis.
Integration of clinical findings, morphology, immunophenotyping, viral detection, and molecular markers like MYD88 L265P is crucial for accurate differentiation.

Impact:

Improved diagnostic accuracy for plasma cell myeloma and related B-cell lymphomas.
Enhanced ability to differentiate between aggressive PCM and B-cell lymphomas with plasmablastic features.
Provides practical criteria for routine diagnostics in hematopathology.