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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

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Related Experiment Video

Updated: May 13, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Hepatitis C virus entry.

Mirjam B Zeisel1, Daniel J Felmlee, Thomas F Baumert

  • 1Inserm, U1110, Strasbourg, France. Mirjam.Zeisel@unistra.fr

Current Topics in Microbiology and Immunology
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) entry into liver cells is crucial for infection. Understanding these interactions aids in developing new antiviral therapies and vaccines against chronic hepatitis C.

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Related Experiment Videos

Last Updated: May 13, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

Area of Science:

  • Virology
  • Hepatology
  • Immunology

Background:

  • Hepatitis C virus (HCV) causes chronic hepatitis and liver disease globally.
  • HCV infection initiates through interactions between viral particles and liver cells (hepatocytes).
  • HCV entry determines its tissue tropism and species specificity.

Purpose of the Study:

  • To review host factors involved in HCV binding and entry.
  • To elucidate molecular mechanisms of HCV entry into target cells.
  • To discuss the significance of HCV entry in disease pathogenesis, therapy, and vaccine development.

Main Methods:

  • Literature review of scientific publications on HCV-host interactions.
  • Analysis of studies on viral entry mechanisms.
  • Synthesis of information on the role of HCV entry in clinical outcomes.

Main Results:

  • Identified key host factors mediating HCV attachment and entry into hepatocytes.
  • Detailed the step-by-step molecular processes of HCV cell entry.
  • Highlighted the link between viral entry mechanisms and disease progression, treatment response, and vaccine efficacy.

Conclusions:

  • Elucidating HCV entry mechanisms is vital for understanding pathogenesis.
  • Targeting HCV entry presents a promising strategy for antiviral drug and vaccine design.
  • Further research into host-virus interactions at the entry stage is critical for combating HCV.