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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Related Experiment Video

Updated: May 13, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Bridging epigenomics and complex disease: the basics.

Raffaele Teperino1, Adelheid Lempradl, J Andrew Pospisilik

  • 1Max-Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.

Cellular and Molecular Life Sciences : CMLS
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

Epigenetics, a layer beyond DNA, influences traits and diseases. Advances in epigenomics are revolutionizing our understanding of complex genetic disorders.

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Last Updated: May 13, 2026

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10:41

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Area of Science:

  • Genomics and Epigenomics
  • Molecular Biology
  • Genetics

Background:

  • DNA sequence dictates gene expression and phenotype, but an additional regulatory network, epigenetics, also plays a crucial role.
  • Epigenetic modifications explain disease discordance in identical twins and influence phenotype independently of genetic blueprint.
  • This regulatory layer involves DNA/histone modifications and noncoding RNAs, impacting chromatin organization and DNA accessibility.

Purpose of the Study:

  • To review the epigenetic basis driving technological advancements in genomics and epigenomics.
  • To explain how these advancements are reshaping the understanding of complex diseases.
  • To provide an accessible overview for newcomers to the field of genomics/epigenomics.

Main Methods:

  • Review of recent technological advances in chromatin state mapping.
  • Analysis of the impact of epigenetics on gene expression and phenotype.
  • Synthesis of current understanding of epigenetics in complex diseases.

Main Results:

  • Technological progress has enabled high-accuracy, comprehensive mapping of chromatin states.
  • Epigenetic mechanisms provide stability and plasticity to genome output.
  • Epigenetic alterations are implicated in the etiology of complex diseases.

Conclusions:

  • Epigenomics has entered a genome-wide era, driven by technological innovation.
  • Understanding epigenetic regulation is crucial for deciphering complex diseases.
  • Continued research in epigenetics promises deeper insights into health and disease.