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Striational antibodies in a paraneoplastic context.
Andrew McKeon1, Vanda A Lennon, Daniel H LaChance
1Department of Medicine and Pathology, Mayo Clinic, Hilton 3-78, 200 First Street SW, Rochester, Minnesota 55905, USA. mckeon.andrew@mayo.edu
Muscle & Nerve
|March 7, 2013
Summary
Striational antibodies (StrAbs) are linked to autoimmune disorders like myasthenia gravis and thymoma. High StrAb titers (≥ 1:7680) or coexisting antibodies may indicate cancer, but low titers generally do not.
Area of Science:
- Neurology
- Immunology
- Oncology
Background:
- The clinical significance of striational antibodies (StrAbs) in paraneoplastic antibody testing remains unclear.
- StrAbs are detected during the evaluation for paraneoplastic antibodies.
Purpose of the Study:
- To determine the clinical significance of striational antibodies (StrAbs).
- To investigate the association between StrAbs and autoimmune disorders or cancer.
Main Methods:
- A comparative study involving 203 StrAb-seropositive patients and age/sex-matched seronegative controls.
- Data collected between 2004 and 2005 during paraneoplastic antibody testing evaluations.
Main Results:
- Striational antibodies (StrAbs) were significantly associated with thymoma and myasthenia gravis (MG).
- Cancer detection (adenocarcinoma, sarcoma) was rare and primarily occurred in patients with high StrAb titers (≥ 1:7680) or coexisting muscle AChR-binding antibodies.
- Increased prevalence of autoimmune disorders including hypothyroidism, rheumatoid arthritis, and pernicious anemia was observed in StrAb-positive patients.
Conclusions:
- Striational antibodies (StrAbs) can serve as a diagnostic indicator for autoimmune conditions.
- Low StrAb titers (< 1:7680) without coexisting paraneoplastic antibodies suggest a low likelihood of underlying cancer.
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