Striational antibodies in a paraneoplastic context
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Published on: September 26, 2012
Andrew McKeon1, Vanda A Lennon, Daniel H LaChance
1Department of Medicine and Pathology, Mayo Clinic, Hilton 3-78, 200 First Street SW, Rochester, Minnesota 55905, USA. mckeon.andrew@mayo.edu
Introduction:
The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown.
Methods:
We compared all 203 striational antibody (StrAb)-seropositive patients identified (2004-2005) during evaluation for paraneoplastic antibodies with age- and sex-matched seronegative controls.
Results:
Thymoma and myasthenia gravis (MG) were significantly more common among cases (P<0.0001). Cancers more rarely detected after StrAb detection were adenocarcinoma in 5 patients and sarcoma in 3 patients. All patients who had a cancer identified after StrAb testing had a titer of ≥ 1:7680 or a coexisting muscle AChR-binding antibody. Autoimmune disorders more commonly observed among cases (with any StrAb value) included: hypothyroidism; rheumatoid arthritis; and pernicious anemia (all P<0.05).
Conclusions:
StrAbs may serve as a diagnostic clue for an autoimmune diagnosis. There is a low likelihood of oncological significance in patients with StrAb titers <1:7680 without coexisting paraneoplastic Abs.
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