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Updated: May 13, 2026
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Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes
Published on: February 22, 2017
Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system
Shlomit Guy1, Dvir Rotem, Zvi Hayouka
1Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
Chemical Communications (Cambridge, England)
|March 7, 2013
Abstract:
Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.
